DISC1 Regulates the Transport of the NUDEL/LIS1/14-3-3 Complex through Kinesin-1
نویسندگان
چکیده
Shinichiro Taya,1 Tomoyasu Shinoda,1 Daisuke Tsuboi,1 Junko Asaki,1 Kumiko Nagai,1 Takao Hikita,1 Setsuko Kuroda,1 Keisuke Kuroda,1 Mariko Shimizu,1 Shinji Hirotsune,2 Akihiro Iwamatsu,3 and Kozo Kaibuchi1 1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya 466-8550, Japan, 2Department of Genetic Disease Research, Graduate School of Medicine, Osaka City University, Abeno, Osaka 545-8585, Japan, and 3Protein Research Network, Yokohama 236-0004, Japan
منابع مشابه
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.
DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function. In cell and animal models, C-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails to interact with binding partners involved in neu...
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Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely transported and functions in cell migration. Here, we show that DISC1-binding zinc finger prot...
متن کاملFunctional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia
The disrupted in schizophrenia 1 (DISC1) gene has been identified as a schizophrenia susceptibility gene based on linkage and single nucleotide polymorphism (SNP) association studies and clinical data, suggesting that risk SNPs impact on hippocampal structure and function. We hypothesized that altered expression of DISC1 and/or its molecular partners (nuclear distribution element-like [NUDEL], ...
متن کاملDISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2.
Disrupted-in-Schizophrenia-1 (DISC1) is a candidate gene for susceptibility of schizophrenia. In the accompanying paper (Taya et al., 2006), we report that DISC1 acts as a linker between Kinesin-1 and DISC1-interacting molecules, such as NudE-like, lissencephaly-1, and 14-3-3epsilon. Here we identified growth factor receptor bound protein 2 (Grb2) as a novel DISC1-interacting molecule. Grb2 act...
متن کاملA LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System
Mutations in mammalian Lis1 (Pafah1b1) result in neuronal migration defects. Several lines of evidence suggest that LIS1 participates in pathways regulating microtubule function, but the molecular mechanisms are unknown. Here, we demonstrate that LIS1 directly interacts with the cytoplasmic dynein heavy chain (CDHC) and NUDEL, a murine homolog of the Aspergillus nidulans nuclear migration mutan...
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